Tight Junction Structure and Function Revisited
نویسندگان
چکیده
منابع مشابه
Physiology and function of the tight junction.
Understanding of tight junctions has evolved from their historical perception as inert solute barriers to recognition of their physiological and biochemical complexity. Many proteins are specifically localized to tight junctions, including cytoplasmic actin-binding proteins and adhesive transmembrane proteins. Among the latter are claudins, which are critical barrier proteins. Current informati...
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Tight junctions form the major paracellular barrier in epithelial tissues. Barrier-sealing properties are quite variable among cell types in terms of electrical resistance, solute and water flux, and charge selectivity. A molecular explanation for this variability appears closer following identification of the transmembrane proteins occludin and members of the claudin multigene family. For exam...
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ژورنال
عنوان ژورنال: Trends in Cell Biology
سال: 2020
ISSN: 0962-8924
DOI: 10.1016/j.tcb.2020.10.001